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drug_recall serzoneBecause of serious safety concerns regarding Serzone, current or prospective patients may search for a Serzone replacement. Serzone (nefazodone) is an antidepressant medication belonging to a family of drugs known as phenylpiperazine. This drug was approved by the FDA in December 1994 and manufactured by Bristol-Meyers Squibb. Serzone is a drug that is chemically unrelated to many other antidepressant medications.
Serzone has been proven to cause serious damage to the liver. Twenty six deaths have been caused by Serzone-induced liver failure. Because Serzone patients are three to four times more likely to suffer liver failure than the general population, this drug was taken off all European and Canadian drug markets in January 2003. In May 2004 Serzone was taken off the market, though it is still available in generic form. Because of these serious risks and the 2004 recall, Serzone replacement medications must be considered for patients seeking antidepressant medication therapy.
Patients should discuss Serzone replacement with their doctors as there are many alternative prescription drugs that can provide benefits similar to Serzone, but without the risk of harmful side effects. All antidepressant Serzone replacement medications have their own set of risks and benefits; therefore it is important to talk to your doctor about your medical history, current condition, and all other relevant issues before deciding which Serzone replacement is right for you.
Antidepressant medications act on the neurotransmitter chemicals in the brain in order to reduce the unfavorable symptoms of depression and some other psychological conditions. Tricyclics are antidepressants that have been used to treat depression for decades and may be good options for Serzone replacement. Tricyclics act on serotonin and norepinephrine and other chemicals in the body. Examples of these Serzone replacement drugs include: Elavil, Norpramin, Tofranil, Aventyl, and Pamelor. These Serzone replacement options all have benefits and side effects that should be considered to determine if these medications are appropriate for you. This class of drugs is associated with blood pressure and heart rate problems. Common side effects from these Serzone replacement drugs include, but are not limited to: dry mouth, blurred vision, constipation, worsening of glaucoma, impaired thinking, fatigue, and trouble urinating.
SRRIs or Selective Serotonin Reuptake Inhibitors are another class of antidepressants that may be considered when looking for a Serzone replacement. As the name suggests, these drugs affect only serotonin chemicals in the brain, which may translate into a lower risk of side effects compared to tricyclics. Lexapro, Celexa, Prozac, Paxil, and Zoloft are all examples of SSRI antidepressant Serzone replacement options. These drugs are also associated with certain risks and benefits that should be discussed with a medical professional. These drugs cannot be taken in conjunction with other drugs, especially MAOIs, or Monoamine Oxidase Inhibitors, which are also potential Serzone replacement drugs. There are a number of other antidepressant medications which may prove viable Serzone replacement options. If you are interested in learning more about a Serzone replacement, you should speak with your health care provider.
Drug manufacturer Bristol-Meyers announced Wednesday that it will no longer make or sell Serzone, an antidepressant that has been linked to potentially deadly liver complications and has already been withdrawn in major markets including Europe and Can...
Public Citizen has sued the FDA, calling the agency "grossly negligent" for failing to issue a Serzone ban despite having already been taken off the market in Canada and Europe, with sales to end in Australia and New Zealand in May. The consumer watchd...