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Seroquel was introduced to the U.S. market as a second-generation antipsychotic drug. Though the introduction of Seroquel and other atypical drugs quickly became popular and doctors commonly prescribed them or switched older antipsychotic patients to the new drug class, Seroquel side effects were serious and sometimes deadly. While all antipsychotic drugs have shown some type of effectiveness in treating "positive" symptoms of psychosis, Seroquel has failed to show an increased efficacy than older drugs in treating the positive or negative symptoms.
Seroquel side effects can include neuroleptic malignant syndrome, fatal instances of heatstroke, and tardive dyskinesia. Tardive dyskinesia is a lifelong condition with no known effective treatment that has been shown to occur among atypical antipsychotic users such as Seroquel. Only if identified in early stages can tardive dyskinesia sometimes be reversed. Especially older patients and women are at risk for suffering Seroquel side effects like tardive dyskinesia.
It was observed among animal testing that another Seroquel side effect was cataracts. Patients using Seroquel therapy must have an eye exam every six months to identify if cataracts are forming. In recent years as well, Seroquel was controversial in that it had been known since the 1970s that women being switched from first-generation antipsychotics to a second generation antipsychotic Clozaril were at an increased risk for unwanted pregnancies. As prescribing atypical antipsychotics became more common, the FDA and Seroquel''s maker were criticized for failing to warn the estimated tens of thousands or more women that were unaware of the fertility risk.
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