Progressive Multifocal Leukoencephalopathy and Multiple Sclerosis

The link between progressive multifocal leukoencephalopathy (PML) and MS (multiple sclerosis) is based on an multiple sclerosis treatment: Tysabri (natalizumab), a once-per-month intravenous infusion. The makers of Tysabri, Biogen-Idec, admit that the use of their product has resulted in at least half a dozen cases of progressive multifocal leukoencephalopathy (PML).

Multiple Sclerosis

In an individual with multiple sclerosis, the body's immune system is attacking his or her brain and spinal cord (i.e., the central nervous system, or CNS). Roughly 400,000 people in the U.S., alone, have multiple sclerosis. There are roughly 2.5 million people around the world struggling with this disease. It's difficult to determine the exact number of multiple sclerosis victims because its symptoms are sometimes not diagnosed correctly, and the symptoms may appear, disappear and then appear again.

Similar Symptoms of MS and PML

The symptoms of multiple sclerosis and the symptoms of progressive multifocal leukoencephalopathy show a good deal of overlap. Each disease is often first observed when the following signs develop:

difficulty walking
loss of coordination
fatigue, weakness
changes in vision
slurred speech

However, the symptoms of PML progress rather rapidly, usually leading to severe disability and death. Although cases of multiple sclerosis can also be disabling and fatal, this occurs much less often compared to PML. With both diseases, the symptoms vary from one person to another, since the damage to the CNS can occur at different sites.

The Link between PML and Tysabri Is Not Understood

Tysabri is not a "drug" per se; it is an antibody (a protein). The exact way that Tysabri works to slow the progression of MS is not known, but it's been theorized that Tysabri inhibits the body's white blood cells from attacking nerves in the brain.

PML is caused by a virus that attacks nerves in the brain. The virus, JCV, is present in many people, but it simply lies dormant until a weakened immune system allows it to become active. Treatments such as Tysabri and Raptiva (a recently recalled psoriasis drug) have produced PML in an alarming number of people.

To learn more about PML, Tysabri, Raptiva and the related issues, contact our progressive multifocal leukoencephalopathy attorneys today. We will connect you with an experienced legal professional, familiar with PML. An attorney for PML victims will be able to help you determine the cause of your condition and whether you are eligible to seek compensation for any losses you have incurred.

Online Lawyer Source

Lawyers & Legal News Near You

Need Legal Help?

Start Here for a Free Case Review!