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Due to the unacceptably high risk of Palladone death from this potent narcotic, the FDA has asked Purdue Pharmaceuticals to pull Palladone off the market less than six months after it was first marketed in the United States. Several reports of Palladone death prompted the recall of this powerful opioid on July 13, 2005. These reports found that patients consuming even one alcoholic beverage while taking Palladone once-daily extended-release pills were at risk for fatal adverse reactions.

Palladone (hydromorphone hydrochloride extended release) is the first drug of its kind ever approved for use in the United States. Drugs like Palladone have been approved in Germany, the UK, and Canada. Before knowledge of Palladone death risks, the FDA approved this drug for the management of persistent moderate to severe chronic pain for patients who have previously taken opioids and require an extended release medication.

Palladone is an opioid in the same family as morphine, oxycontin, fentanyl, and oxymorphone. Use of these drugs carries the highest risk of death from overdose, and the highest potential for abuse. Because these drugs are so dangerous, the government has taken aggressive steps to prevent misuse and abuse of these drugs.

Like Oxycontin, Palladone is a time-release capsule that slowly and steadily delivers powerful pain relief over a 24 hour period. Palladone death can result when any non-opioid tolerant individual takes this medication. Palladone must be swallowed whole. If the capsules are crushed, broken, dissolved, or chewed the person may suffer an overdose leading to Palladone death.

A Palladone death from overdose of this medication is typically the result of respiratory depression. When too much of the drug is absorbed into the bloodstream, the central nervous system becomes dangerously depressed. The symptoms of a Palladone overdose can include: slowed breathing, stupor, coma, muscle flaccidity, constricted pupils, abnormal heart beat, low blood pressure, clammy cold skin, and even Palladone death.

In addition to general overdose due to lack of tolerance or over consumption, Palladone death can also result from mixing the drug with even one alcoholic drink. Researchers have found that alcohol causes Palladone dose-dumping. Dose dumping is the rapid release of the active ingredient in an extended-release drug into the blood stream. Dose-dumping actually produces an overdose, even in opioid tolerant patients, and can lead to Palladone death.

The Palladone warning label has included the standard warning about mixing alcohol with drugs of this kind, but did not adequately inform medical professionals and consumers about the serious risks of Palladone death associated with prescription medication. Palladone death reports came from a Purdue-sponsored study and no reports of Palladone death have yet been reported in the general patient population. If you or a loved one has taken Palladone, you may wish to contact us to confer with a qualified attorney you can evaluate your case to ensure that your legal interests are protected.

"Palladone pulled from the market after just five months"

The U.S. Food and Drug Administration has asked Purdue Pharma to stop the sale and marketing of its potent new pain drug, Palladone, after just five months on the market. The decision was made after the agency acquired new information regarding the in...

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