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Patients who have had fractures of the hip, spine, or wrist while taking a proton pump inhibitor (PPI) such as Nexium® (esomeprazole magnesium) might consider filing a lawsuit against the maker of the drug.

The U.S. Food and Drug Administration (FDA) announced a possible link between PPIs and such fractures. After reviewing numerous epidemiological studies that included a large number of patients, the FDA concluded there might be a potential link between medications such as Nexium® and Prilosec®® and hip, wrist and spine fractures.

A PPI is a drug that is in a class of medications used to block the production of acid in the stomach. While stomach acid’s purpose is to help digest food, the acid can flow backwards up the esophagus (the tube connecting the mouth and stomach) and cause irritation and sores. PPIs are also used to treat ulcers, heartburn and erosive esophagitis. The latter can cause the esophagus to swell or parts of it to erode away.

Common prescription PPIs include:

• Nexium®
• Dexilant™
• Prilosec®®
• Zegerid®
• Prevacid®
• Protonix®
• Aciphex®
• Vimovo™

Consumers can buy the following over-the-counter medications without a prescription:

• Prilosec®® OTC
• Zegerid® OTC
• Prevacid® 24HR

The link between the fractures and PPIs has been found in epidemiologic studies (backward-looking studies that do not show cause and effect but can show a link). But, no clinical trials (controlled, forward-looking studies that can predict cause and effect) up to this point have shown a definitive cause and effect connection.

The epidemiologic studies linked long-term use (more than a year) and higher doses with a risk of fractures. The FDA plans to evaluate data from a number of large, long-term controlled clinical trials of medications used to prevent fractures in women. The purpose of the study will be to determine the risk of fractures in these women, comparing patients who used or did not use PPIs.

The FDA’s announcement cautioned physicians prescribing such medications to be aware of the possibility of an increased risk in their patients for fractures and balance the advantages of taking them against the chance of fracture.

Talk to a Nexium® Lawyer About a Lawsuit

If you have taken a PPI and subsequently suffered from a bone fracture, you may be entitled to see out compensation. To find out if you qualify to file a lawsuit, contact a Nexium® lawyer. Our network of drug attorneys investigate cases nationwide.