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February 20th, 2004
"Elderly Warned of Off-Label Zyprexa Use"
Zyprexa''s maker Eli Lilly & Co. announced it had warned doctors of using Zyprexa schizophrenia treatment amongst elderly patients with dementia. A letter was issued to U.S. doctors on January 15, 2004 to warn of increased risks of death and stroke when elderly patients with dementia were prescribed Zyprexa.
The Zyprexa warning closely resembles the April 2003 Johnson & Johnson warning for its schizophrenia drug Risperdal, which also warned of risks of stroke among elderly patients with dementia. Public Citizen consumer group has been very critical of the practice in prescribing schizophrenia drugs to treat symptoms of dementia since it has never been approved to treat it.
Contained in the Zyprexa warning letter was the observation that 3.5% of elderly patients with dementia being treated on Zyprexa in the trials died of all causes. This figure is more than twice the death rate of patients taking placebos. Zyprexa had global sales of $4.3 billion in 2003 alone, accounting for half of Lilly''s profits.
