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The FDA recently issued a public health advisory warning certain antidepressants can cause sudden worsening of symptoms. The agency recommended manufacturers add new warnings to prescription inserts for antidepressants Prozac, Paxil, Zoloft, Luvox, Celexa, Lexapro, Wellbutrin, Effexor, Serzone, and Remeron. Physicians were also warned to closely monitor patients taking the antidepressants for signs of mental status changes.
A recent UK study on 1300 adolescents was given Paxil or an inactive placebo. Researchers found the rate of increased suicidal symptoms was 1.2 percent for the placebo versus 3.4 percent for the Paxil group. It was noted that there were no actual suicides but 33 suicidal incidents. Important findings were that in the Paxil group almost all of the suicidal symptoms occurred in the first two weeks and during the 28 days following the study when the patients were being taken off Paxil.
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