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A drug usually prescribed for arthritis has shown a marked effect on the asbestos-related cancer malignant mesothelioma in lab and animal experiments, according to a report from Italy.
The COX-2 inhibitor Celebrex has been shown to stop mesothelioma cells growing in a lab dish. No current treatments for mesothelioma have been able to stop the progress of the disease, according to authors of the report that appeared in the International Journal of Cancer. These findings led Dr. Alfonso Catalano and his colleagues at the University of Marche in Ancona to assess the effects of Celebrex on experimental mesothelioma.
Celebrex and similar compounds inhibited the proliferation of a mesothelioma cell line without interfering with the growth of a normal mesothelial cell line. Celebrex was the most effective of the various agents tested.
When tested in mice implanted with mesothelioma, Celebrex treatment significantly increase the average survival from 45 days to 62 days, and there were three long-term survivors (more than 120 days) among the treated mice.
"These results provide the first evidence that celecoxib (Celebrex) is effective for the prevention and regression of malignant mesothelioma cells in experimental models. and strongly support ongoing clinical trials in malignant mesothelioma patients," the team''s report concludes.
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