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A recent study has found that the adverse side effects associated with isotretinoin, the active ingredient in Accutane®, may be reduced if the patient takes smaller doses.
The study, led by Marius Rademaker, was conducted at the Tristram Clinic in Hamilton, New Zealand. The findings of the study were published in a recent issue of the Australian Journal of Dermatology.
Rademaker and his colleagues reviewed the cases of 1,743 patients who took isotretinoin, which is typically used to fight acne, over a six-year period. Their findings revealed a strong link between the occurrence of adverse side effects and the size of the dosage.
The study found that patients who took 0.25 mg or less of isotretinoin each day suffered from cheilitis, a condition that causes lip inflammation, in 47 percent of cases as opposed to 97 percent of the cases wherein the patient took a higher dose. Seven percent of those taking the smaller dose experienced tiredness while 18 percent of those taking more isotretinoin suffered from the condition.
Accutane® was introduced to the market in the 1980s to fight acne, but it was recently discontinued in part because of its side effects.
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