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drug_recall naproxenNaproxen effects on the cardiovascular system have been the subject of recent controversy following the publication of preliminary clinical trial evidence. The National Institutes of Health began a three year study called ADAPT in 2001 to study naproxen effects on the prevention of Alzheimer''s disease. This study was halted in late 2004 after preliminary trial results indicated that patients taking naproxen were twice as likely to suffer heart attack or stroke as patients in taking a placebo pill.
These adverse naproxen effects caused injury to seventy five of the 2,500 study participants taking this medication. All of the affected participants experienced these naproxen effects while taking over-the-counter level doses of naproxen. This study was concurrently testing the effectiveness of Celebrex, a drug similar to naproxen, in preventing Alzheimer''s disease. The group of trial participants taking Celebrex did not experience the naproxen effects associated with the naproxen group.
Naproxen is the generic name for a group of over-the-counter and prescription strength original non-steroidal anti-inflammatory drugs (NSAIDs). These drugs are used to treat the pain, stiffness, and inflammation caused by several conditions including osteoarthritis, rheumatoid arthritis, tendonitis, traumatic injury, and severe menstrual cramps. Aleve is the well known over-the-counter naproxen medication that has been available on the US market since the mid-1970s. Prescription strength naproxen medications include Naprosyn, Anaprox, and Naprelan.
Naproxen effects have the potential to cause adverse gastrointestinal side effects in patients taking this medication. Adverse naproxen effects may also be more likely in patients who are allergic to similar medications, have kidney or liver problems, certain blood disorders, heart problems, and high blood pressure. Patients who consume alcohol regularly may also be at an increased risk of adverse naproxen effects. Naproxen effects may also have the potential to cause injury to newborns; therefore, patients who are in their third trimester of pregnancy or who are currently nursing are advised not to take naproxen.
In response to new evidence suggesting potential adverse naproxen effects with respect to cardiovascular health, drug regulators, researchers, and physicians are beginning to evaluate clinical trial information and conduct further research. It is still possible that this new information about naproxen effects is statistically insignificant. Until the further investigations are conducted, physicians are urging patients to be aware of these potential naproxen effects. Doctors recommend that patients currently taking naproxen take this medication exactly as directed or prescribed. People who plan to take this medication for more than ten consecutive days should first speak to their doctor about potential naproxen effects and the benefit of this longer-term use.
If you have questions about adverse naproxen effects or experience any undesirable side effects while taking this medication, you may wish to speak to your physician about naproxen effects.
The FDA says it is working with the National Institutes of Health to review available scientific information on naproxen, sold under the brand name Aleve by Bayer, after the decision to halt a clinical trial studying the effect of naproxen on patients...