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Fentanyl spray — whether an intranasal spray or a sublingual (under the tongue) spray — is not yet widely available for patients in the U.S. Fentanyl citrate is the synthetic opioid medication that has been used since the 1960s for chronic pain and breakthrough cancer pain in patients all over the world, in formulations such as:

• fentanyl transdermal systems (e.g., fentanyl patches)
• intravenous fentanyl
• buccal (between the cheek and gum) tablets
• fentanyl lollipops, lozenges, and effervescent tablets

Fentanyl Spray as a Delivery System

Each of these fentanyl delivery systems has its own advantages and drawbacks. Various Fentanyl spray methods have been proposed for different reasons, such as their:

• ease of use (particularly for pediatric patients and patients who are not to receive pain medication by mouth) by both healthcare professionals and appropriate patients
• less invasive nature compared to intravenous injections
• fast onset — especially desirable for breakthrough pain
• short duration — also appropriate for the short bouts of breakthrough pain

Fentanyl Sprays for Breakthrough Pain

"Breakthrough" pain is a transient worsening of pain that is experienced by an individual who is already taking pain medication for "background" pain. Cancer patients, for example, often experience several episodes of breakthrough pain each day — severe, fast-onset pain that lasts roughly 30 minutes to an hour. A fast-onset delivery system for fentanyl could be very effective for treating these difficult episodes.

An Intranasal Fentanyl Spray Clinical Trial

A clinical trial testing various doses of a Fentanyl intranasal spray was conducted in 2007. In a double-blind, randomized study, nearly 160 cancer patients who were experiencing breakthrough pain were given unmarked nasal sprays containing a placebo or Fentanyl at 50, 100 or 200 micrograms of fentanyl.

Each patient could randomly use the spray devices (and they did not know what was in any of them). Significant relief from the pain was reported at 10 minutes post-spray in 29 percent, 42 percent, and 50 percent of the patients who used the 50, 100, and 200 mcg doses, respectively.

Fentanyl Sprays Could Be Dangerous

However, a disadvantage (or danger) of a Fentanyl spray may be the same aspect considered an advantage: the fast onset. The spray may act too quickly and in too strong a dose if not administered correctly. A patient could potentially receive too much Fentanyl far too quickly via the intranasal or sublingual Fentanyl spray route.

Such an overdose of Fentanyl could have devastating results — including death. Learn more about Fentanyl dangers: contact a Fentanyl lawyer today.