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Does Crestor Cause Heart Failure?

Statin drugs such as Crestor may be linked to heart failure and cardiomyopathy (disease of the heart muscle), a recent clinical trial suggests.

The trial is called the GISSI-HF trial. One explanation the researchers gave is that statins (cholesterol-lowering drugs) are recognized for reducing the concentration of coenzyme Q10. Lower levels of coenzyme Q10 have been known to worsen heart failure. Additional clinical studies are underway.

Symptoms of Heart Failure

Symptoms of heart failure include:

• Being short of breath
• Tightness in the chest
• Wheezing
• Coughing up frothy mucus
• Breathing problems interfering with sleep
• Needing to use pillows to prop you up to breathe during sleep
• Fainting
• Slowed heart rate
• Swelling of the feet or legs

Complications of Heart Failure

How well you do when you have heart failure depends on the cause for the condition, how severe it is, your overall health, and other influences such as age. The following complications can result from heart failure:

• Kidney damage or kidney failure due to reduced blood flow to kidneys
• Damaged heart valves due to buildup of fluid and blood
• Liver damage due to fluid buildup and scarring of the liver
• Formation of blood clots that can cause heart attack and stroke

Proper treatment will enable some patients to improve after heart failure. But, the condition can be life threatening and cause sudden death. If the condition is severe enough, heart transplantation or an artificial device may be necessary.

Heart Failure Treatment

Heart failure needs to be managed for the duration of a patient’s life. Treatment can help to improve some symptoms of the disease and the heart can grow stronger. Treating the underlying reason for the condition is important and may undo the heart failure in some patients. Most patients, however, need a combination of the right medications and sometimes devices that help improve heartbeat and contraction.

Medications that are used to treat heart failure include:

• Angiotensin-converting enzyme (ACE) inhibitors (such as Vasotec, Prinivil, Zestril and Capoten)
• Angiotensin II receptor blockers (ARBs) (such as Cozaar and Diovan)
• Digoxin (Lanoxin)
• Beta blockers (such as Coreg, Lopressor, and Zebeta)
• Diuretics (such as Lasix and Bumex)
• Aldosterone antagonists (such as Aldactone and Inspra)

Other medications may be prescribed as well, including nitrates for chest pain, a statin to lower cholesterol, and a blood thinning medication.

Surgery and medical devices also may be used to treat heart failure. These include:

• Coronary bypass surgery
• Heart valve repair or replacement
• Implantable cardioverter defibrillators
• Biventricular pacemaker
• Heart pumps
• Heart transplant

If you are taking Crestor and experienced worsened heart failure, you should speak with an attorney about the possibility of filing a lawsuit to seek compensation for your injuries. You might be eligible for compensation for your medical bills, lost wages and pain and suffering.

"Possible Crestor®-Heart Failure Link"

Some researchers believe the cholesterol medication Crestor® (rosuvastatin) can increase the severity of heart failure in certain patients.

Coenzyme Q10 (CoQ10), pro...

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"FDA rejects petition to ban Crestor"

The consumer advocacy group Public Citizen submitted a petition to the FDA a year ago asking the agency to immediately withdraw the anti-cholesterol drug Crestor, but the agency has denied its request.

Crestor belongs to a group of drugs ...

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"Asians taking Crestor may be at higher risk for rhabdomyolysis"

The FDA has announced that Crestor is being relabeled to add a warning that starter doses should be reduced in Asian-American patients, as well as some other higher risk patients.

A clinical trial found that levels in Asian patients were d...

» Read More