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Byetta and muscle and joint pain are mentioned frequently in Internet forums that bring to light the personal experiences of patients on various medications. Byetta (exenatide) is the injectable pen device for controlling the blood sugar of adults with type 2 diabetes. The twice-daily Byetta injections are often used in conjunction with a sulfonylurea drug and metformin as a treatment for diabetes, and some Byetta users have reported muscle pain and/or joint pain as a side effect of this diabetes regimen.

Muscle and Joint Pain from Byetta Side Effects

There are many potential side effects of Byetta, and some of them — such as hypoglycemia, or abnormally low blood sugar — can result in muscle and joint pain or other problems affecting the muscles and/or joints. Diabetic individuals already have enough challenges with health problems of various types, and extra muscle or joint pain from a medication such as Byetta is not desired. Some of the health issues that are more common among people with diabetes are:

• Peripheral arterial disease (PAD) — a complication of diabetes affecting one-third of people with diabetes over the age of 50, PAD can cause significant leg muscle pain
• High triglyceride levels — the medication to treat this condition often causes muscle and joint pain
• Diabetic neuropathy (nerve damage) — carpal tunnel syndrome and tarsal tunnel syndrome in diabetics can lead to muscle and joint pain and weakness
• Hypoglycemia

Byetta and Knee Pain

The knee pain linked to Byetta use is a similar issue. When Byetta use results in hypoglycemia, a shortage of glucose in the brain may occur. Glucose is the brain's "fuel." A number of dangerous symptoms signal hypoglycemia, including:

• knee pain
• weakness of the limbs
• muscle and joint pain
• tremors and chills
• seizures
• coma

Any Byetta patient who has hypoglycemia should seek emergency medical care.

Byetta, Dehydration and Muscle Pain

Two other common side effects of Byetta use are nausea and vomiting. These Byetta problems often occur in the first weeks of its use, but they usually resolve with time. Continued nausea and vomiting can cause dehydration, another dangerous complication.

Dehydration symptoms include muscle cramps and a "tingling" sensation in the muscles of the hands, feet, arms and legs. In addition, the unexplained, extreme fatigue that can accompany dehydration may be accompanied by muscle and joint pain and weakness.

For more information about dangerous Byetta side effects, consult a Byetta lawyer.