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Associated to the use of diet drugs, including Fen Phen, Redux, and Pondimin, pulmonary hypertension begins when the small vessels supplying blood to the lungs constrict, making it more difficult for blood to pass to the lungs. The heart must pump harder as a result, leading to scarring of the vessels and completely blocking them in some instances. Bosentan and Remodulin are two drug treatments intended to relieve symptoms of pulmonary hypertension since there is no cure identified as of yet.

Bosentan tablets work by blocking the hormone endothelin that has been found to exist in a higher level with pulmonary hypertension and is harmful to the lung and pulmonary arteries. Bosentan lowers the endothelin level to reverse the effects of hypertension created because the damaged lung and pulmonary arteries have created a blood flow resistance.

Remodulin is also used to treat pulmonary hypertension in the form of a synthetic, stable form of prostacyclin. Remodulin has the ability to last for a longer period of time opposed to other pulmonary hypertension drug alternatives like Flolan, which must be constantly infused. Remodulin is still in Phase III trials used for FDA approval to market the drug. One of the largest benefits to Remodulin therapy is the under the skin deliver called subcutaneous infusion. The use of Remodulin, due to the microinfusion device, reduces the risk of sepsis infection and hospitalization.

"Bosentan side effect risks may soon be replaced with erectile dysfunction drugs"

Pulmonary arterial hypertension (PAH) is a rare disorder that strikes mostly women in the prime of their lives. The disorder elevates the blood pressure in the artery between the heart and lungs and usually proves to be fatally within three years of th...

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