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The heart surgery drug Trasylol (aprontinin) has been correlated with a heightened risk of kidney failure. Trasylol is commonly prescribed to patients undergoing heart surgery for blocked coronary arteries and other more complicated cardiovascular complications to control bleeding and induce clotting. An independent study released in January of 2006 suggests that the severity of Trasylol kidney failure risk may be as high as twice the risk of alternative medications, in addition to posing other serious side effects such as heart attack, stroke, and heart failure.

The Study

Pharmaceutical company, Bayer AG released Trasylol in 1993 following approval from the Food and Drug Administration. Reports of consistent adverse side effects have led researchers to believe that pretrial testing for the drug was insufficient. Dr. Dennis T. Mangano, who facilitated the research on Trasylol kidney failure, studied a sampling of heart surgery patients that was comprised of people taking Trasylol, people taking alternative medications, and those taking no medication at all for controlling blood loss.

Trasylol Side Effects

In addition to exhibiting double the risk for Trasylol kidney failure, patients taking the medication showed a 50 percent increased risk of heart attack, a 109 percent increase in risk of heart failure, and an alarming 181 percent increased risk of experiencing a stroke . Patients taking alternative medications comparatively experienced no signs of increased risk for kidney failure or any of the other adverse side effects.

Many doctors and surgeons involved with cardiovascular healthcare have expressed concern regarding Trasylol kidney failure since the initial release of the drug. However, results of the independent study are only now expected to impact sales and availability of Trasylol. Bayer has responded to the newly reported findings with skepticism, alleging that substantial testing was conducted prior to and during the drugs availability and produced results inconsistent with Dr. Mangano''s findings.

Alternative Medications

Alternative medications for controlling bleeding during heart surgery such as aminocaproic acid and tranexamic acid have proven to be safe and effective substitutes for Trasylol that do not present the same serious side effects. Patients involved in Dr. Mangano''s research who were taking Trasylol alternatives, showed no signs of increased risk for Trasylol kidney failure, heart attack, or stroke. Aminocaproic acid and tranexamic acid are also significantly less costly options in comparison with Trasylol.

Researchers have estimated had alternative medications been used as opposed to Trasylol, $1 billion in healthcare costs could have been saved.

Dr. Mangano has commented that he could not in good conscious give Trasylol to any patient knowing that there are safe and effective alternative medications. “The least that should be done is to inform the patient that the risk of going on dialysis is increased 2 to 3 fold and there are alternatives,” the doctor added.

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