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Trasylol® — a drug used to decrease blood loss during heart surgery—can double a patient''s risk of kidney failure, heart attack, stroke, and death , according to a January 2006 study published in the New England Journal of Medicine .

The Trasylol® study: serious drug side effects

The recent Trasylol® study was published by Dr. Dennis Mangano and colleagues at the Ischemic Research and Education Foundation in northern California. Researchers found that in a study of over 4,300 patients at 70 centers around the globe, those treated with Trasylol® during heart surgery were TWO TIMES more likely to suffer kidney failure, heart attack, stroke, and even death, compared to those given generic alternatives or no medication at all.

Trasylol® is also linked to a small, but significant, risk of allergic reaction. Information about this Trasylol® side effect has been included as a boxed warning on all drug labeling for years. No mention of the other serious Trasylol® side effects has ever been included on the drug''s labeling.

Alternatives to Trasylol®

According to the study, two generic alternatives to Trasylol®— aminocaproic acid and tranexamic acid— provide the same benefits as Trasylol®, WITHOUT the serious risk of life-threatening Trasylol® side effects. These generic Trasylol® alternatives are also much less expense.

According to Mangano and colleagues, using one of the generic drugs instead of Trasylol® could prevent over 11,000 kidney complications, save over one billion dollars in healthcare, and reduce drug costs by $250 million worldwide.

The researchers estimate that up to 10,000 people are currently on kidney dialysis due to Trasylol® side effects.

What is Trasylol®?

Trasylol® is a proteinase inhibitor that is used during cardiopulmonary bypass in patients undergoing coronary artery bypass graft (CABG) surgery. Trasylol® has been used for 13 years in over 60 countries to reduce bleeding during heart surgery . The FDA approved Trasylol® in 1993, which has since been administered to over one million people worldwide. Trasylol®—whose drug name is aprotinin—is made by Bayer AG .

“Trasylol® worse than Vioxx®”

Experts are saying the serious side effects associated with Trasylol® are worse than the serious drug side effects associated with the infamous painkiller Vioxx®. According to Mangano, “the frequency of adverse events we see is FAR GREATER with Trasylol® than with Vioxx®.” The dangers of Trasylol® are also more serious because this drug has been administered for over 13 years.

What does this mean?

“ The study raises serious concerns about the continued use of Trasylol® and suggests far less expensive alternatives are available that are equally effective and safe ,” states Mangano and his team of researchers.

He also adds that if a doctor chooses to use Trasylol® , given the recent discovery of its serious drug side effects, his or her actions are going to be hard to defend if the patient develops kidney failure or another serious complication.

This unequivocal statement indicates that experts believe Trasylol® is not safe for consumer use.

"Trasylol Linked to Risk of Death"

A rigorous study involving the heart surgery drug Trasylol is likely to seal the drug’s fate, as researchers are left with little doubt of the greater ...

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"Heart Surgery Drug Risks Confirmed"

The heart surgery drug, Trasylol, increases the risk of death and kidney damage in patients, two new studies have confirmed.

Trasylol (aprotinin) is given to patien...

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"FDA Suspends Sale of Trasylol Because of Death Risk"

Sales of the heart surgery drug Trasylol are being suspended as concerns continue to mount over the increased risk of death, the Food and Drug Administration announced Monday...

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Trasylol - The Official Site of Trasylol Aprotinin Injection by Bayer Pharmaceuticals Corporation

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