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Acetaminophen and liver damage is considered a very serious risk of the pain reliever and ingredient found in over 200 over the counter drugs. The link between acetaminophen and liver damage was discovered early, though the FDA did not warn of the safety risk until later. In 1977, the FDA’s own advisory committee recommended a warning of acetaminophen and liver damage be put on products, but the FDA chose to disregard it.
In September 2002, the Public Citizen consumer group made a statement on safety issues related to acetaminophen in front of the non-prescription drugs advisory committee. Included in the watchdog group’s statement were the concern of acetaminophen and liver damage and the lack of safety precautions taken. The consumer group criticized the existing acetaminophen and liver damage warning. From 1976 to 1999, there was almost double the number of fatal acetaminophen associated poisonings.
The FDA Non-Prescription Drugs Advisory Committee finally discussed safety issues with acetaminophen use and included a “Use Caution With Pain Relievers” article in the FDA Consumer magazine in the Jan/Feb 2003 issue. By standardizing liquid formulations, the Public Citizen consumer group believes the number of acetaminophen and liver damage suffered in pediatric cases can be reduced. Cases of liver toxicity that had been reported between January 1998 and July 2001 were the result of unintentional overdose.
Acetaminophen and liver damage risk reduction can also be achieved by removing “irrational” over the counter acetaminophen sales according to the Public Citizen. Since a quarter of acetaminophen and liver damage cases collected by the FDA was amongst consumers using more than one acetaminophen-containing product, the removal of combination products may help any consumer confusion.
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