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Acetaminophen is a pain reliever ingredient found in many different over the counter medications and prescription medications. The number one choice of painkiller in the U.S. is Tylenol, a brand name for acetaminophen. Generally considered a safe and effective pain reliever option, acetaminophen still has very serious dangers that were worrisome enough to lead the Public Citizen consumer group to make a statement in front of the FDA Non-Prescription Drugs Advisory Committee in September 2002.
The FDA’s own advisory panel first recommended safety warnings for acetaminophen-containing products in 1977. The use of acetaminophen in excess or for an extended period of more than 10 days was shown to cause risk of severe liver damage according to the advisory panel. The FDA chose to go against the advisory panel’s recommendation and did not warn of the link between acetaminophen use and severe liver damage.
Considered the most common cause of drug-induced liver failure, acetaminophen is found in over 200 over the counter products. Since acetaminophen is a common remedy for symptoms such as pain, fever, colds, and coughs, a statement on behalf of The American Liver Foundation provided to the FDA’s advisory committee was worried that present marketing practices of acetaminophen containing products makes it difficult to determine the standard dose. In the January-February 2003 FDA Consumer magazine, the FDA included an article entitled “Use Caution With Pain Relievers” to warn of acetaminophen adverse effects.
Acetaminophen has also been linked to 141 deaths in 1999 and many of the cases were determined to be intentional overdoses.
eMedicine - Toxicity, Acetaminophen : Article by Susan E Farrell, MD
Understanding Acetaminophen Poisoning - A protein known as CAR (constitutive androstane receptor) has been shown to regulate liver toxicity caused by the common pain-reliever acetaminophen in studies that point the way to new treatment for poisoning with similar compounds, said scientists at Baylor College of Medicine in the journal Science.
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