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Due to the significant PPH symptoms and the short life span associated to PPH, developing an effective PPH treatment continues to be the focus. With just a three-year life expectancy when receiving a PPH diagnosis associated to the condition in the 1990s, the use of certain drug therapies has been shown to increase the life expectancy of some PPH suffering patients. Unfortunately, many therapeutic modalities are very complex and require intensive and ongoing follow-ups.

Since PPH had been a very rare occurrence, appearing in just 1 in 500,000 people normally, most clinicians and medical centers were not properly experienced or knowledgeable on PPH treatment to provide an effective and well-managed plan. Unfortunately, the high popularity of the recalled diet drugs Fen Phen, Redux, and Pondimin was associated to primary pulmonary hypertension and had an occurrence of PPH in 1 in 20,000 users. With an estimated 6-7 million Americans having used Fen Phen prior to the diet drug recall, the number, later thought grossly underestimated, has affected countless amounts of people.

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